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Which process adds a water-soluble substance to the active site on the molecule during detoxification?

  1. Phase I activation

  2. Phase II conjugation

  3. Protein synthesis

  4. SAM production

The correct answer is: Phase I activation

Phase I activation does not add a water-soluble substance to the active site during detoxification. Instead, it modifies the molecule to make it more reactive and easier to bind with water-soluble substances during phase II conjugation. Option B, Phase II conjugation, is the correct process as it involves the addition of water-soluble substances to the active site, making the detoxified molecule easier for the body to eliminate. Option C, protein synthesis, is incorrect because it refers to the creation of new proteins and does not involve modifying molecules in the detoxification process. Option D, SAM production, is also incorrect as it refers to the production of S-adenosyl methionine, a molecule involved in cellular reactions but not specifically related to detoxification.