NANP Board Practice Exam

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Prepare for the NANP Board Exam. Study with detailed questions and explanations on key topics. Enhance your understanding and boost your confidence for the exam.

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Which hormone circulates in the blood unbound?

Cortisol
Epinephrine
Glucagon
Insulin

The correct answer is: Glucagon

Glucagon is the hormone that circulates in the blood unbound. This is because unlike the other options, it is a protein hormone that is not bound to any binding proteins in the blood. Cortisol is a steroid hormone and is bound to corticosteroid binding globulin in the blood. Epinephrine and insulin are both peptide hormones and are bound to carrier proteins in the blood. This is necessary for their stability and transportation to their target tissues. Only glucagon is able to circulate unbound, allowing it to quickly reach its target cells and exert its effects.