NANP Board Practice Exam

What is the role of Glycine in biotransformation?

1. Conversion to methionine

2. Important in biotransformation of carboxylic acids and heterocyclic amines

3. Regulates calcium availability

4. Sulfur donor for Phase II detox pathways

The correct answer is: Conversion to methionine

The correct role of glycine in biotransformation is significant in the context of its involvement in various metabolic processes, particularly in the conjugation of carboxylic acids and heterocyclic amines, which links to detoxification mechanisms. Glycine acts as an amino acid that participates in the synthesis of bile acids and is also involved in the detoxification of certain compounds by facilitating their excretion from the body. In processes like conjugation, glycine can combine with toxic substances to make them more water-soluble, enhancing their excretion. This is part of Phase II detoxification pathways, where the body modifies lipophilic chemicals into more hydrophilic forms for easier elimination. Understanding glycine's role in this capacity illustrates its importance in maintaining homeostasis and managing biochemical pathways relevant to detoxification. The other choices suggest different roles or incorrect associations with glycine that do not align with its established functions in biotransformation.